When it comes to overcoming drug addiction, the endocannabinoid system (ECS), is a double-edge sword. On one hand, it helps regulate homeostasis; when the body functions in a state of homeostasis, it is free of disease and working optimally. However, the ECS, as the Substance Abuse research says, has been shown to influence the acquisition and maintenance of drug-seeking behaviors, through its role in reward and brain plasticity.